Background: Matrix Rhythm Therapy (MaRhyThe^©) is a recent advancement in the field of physiotherapy. It is a treatment instrument which helps in enactment and equalization of the typical physiological vibrations of the skeletal muscles and the sensory system. Objective: To describe the effect of MaRhyThe^© as an adjunct in patients in heterogeneous ulcers of the leg. Design: Case series. Setting: Orthopedic and physiotherapy center in Solapur. Patients: Five cases with heterogeneous leg ulcers from a single center were recruited and were treated with MaRhyThe^©, a handheld resonator by trained therapists. The cases have all received appropriate therapies, however, they failed to heal before the referral. The ulcers were measured before the start of therapy and MaRhyThe^© was applied around the wound edges and the whole of the affected limb. Most cases received 60 minutes of therapy once weekly or twice weekly depending on the size of the ulcer until the absence of the wound. All cases were followed up regularly to confirm wound closure posttreatment period. Results: The median age was 50 (38–65) years. The nonhealing median period was 13 (8–16) weeks. The underlying cause of the ulcer was trauma and pressure sores. The median time to healing was 4 (2–8) weeks. In all cases, proliferation was observed following on from the first treatment session and improved with every therapy week until wound closure. Conclusion: Matrix Rhythm Therapy is a noninvasive, safe therapy and effective in treating heterogeneous ulcers of a leg in these retrospective cases.