Background: Chronic osteomyelitis of metatarsals is commonly seen in patients with diabetic foot disease or following open fractures of the foot. However, it is extremely rare for chronic osteomyelitis of the forefoot to occur in the absence of an immunocompromised state. There has been one case report describing osteomyelitis of the first metatarsal head in an immunocompetent female. Here we present a case report of a young female without any immunocompromise presenting with forefoot osteomyelitis managed successfully in a staged manner. Case description: A 34-year-old woman presented to our Outpatient department with pain involving her right forefoot for the past 14 weeks and discharging sinus on the sole for the past 6 weeks. Clinical examination revealed the instability of the first three metatarsophalangeal (MTP) joints. Radiological and hematological investigations confirmed forefoot osteomyelitis. Local and systemic immunocompromise was ruled out by a detailed evaluation. AOFAS Hallux score was recorded as 36. In the first stage, she underwent debridement and trans-articular K-wire fixation of the affected joints. Later she was taken up for a fusion of the first MTP joint using Synthes Hallux locking fusion plate. Clinical and radiological fusion was discernible by the end of 12 weeks. AOFAS Hallux score at the end of 6 months and 12 months was 84 and 92, respectively. There was no sign of recurrence of infection until the last follow-up. Conclusion: Chronic osteomyelitis of the forefoot in immunocompetent individuals is a rare clinical presentation. A satisfactory outcome in the form of a pain-free functional foot can be achieved by either joint fusion or salvage provided the infection is controlled. Clinical significance: Thorough evaluation is needed to rule out a local or systemic immune compromise in forefoot osteomyelitis in the absence of trauma. Regardless of the underlying etiology, the principles of management should be infection control and stabilization of the involved joints.