Aim: Footwear modification with lateral elevation in the sole is considered an easy to administer and low-cost orthotic intervention for knee osteoarthritis, yet it is not routinely prescribed because of limited available data to prove its effectiveness. This study aimed to assess the effect of lateral wedging in footwear, quantitatively. Materials and methods: We used Zebris Foot pressure platforms integrated into Gait Analysis Laboratory for foot pressure assessment. A Prospective Pre-Post Interventional Study was conducted with 40 patients in the age-group 35–75 years who attended Physical Medicine and Rehabilitation (PMR) OPD with grade II and three osteoarthritis on Kellgren and Lawrence System affecting the medial compartment of the knee. Baseline evaluation was done without orthotic modification in footwear and then repeated after ¼ inches lateral wedge orthosis was given in footwear. Results and implications: Peak plantar pressures showed a trend of a shift toward the lateral zone of the foot after wearing lateral-wedged insoles in shoes, signifying the redistribution of pressure and change in the ground reaction forces in the patients with osteoarthritis knee after shoe modification. All patients reported relief in pain scores. Hence lateral wedging provides symptomatic benefits. Conclusion: In low-income nations, orthotic intervention has a lot of potential as a simple and economical treatment for knee osteoarthritis (KOA). Furthermore, our findings point toward the relevance of conservative management and its ability to slow disease progression, which could be extremely helpful for people with KOA who are not candidates for surgery.