Keywords :
Ankle, Benign, Case report, Foot tumors, Tibial nerve
Citation Information :
Gupta S, Khurana A, Jaggi K, Singh DK, Malhotra R, Rajpal K. Giant Schwannoma of Foot: A Report of Two Cases and Literature Review. J Foot Ankle Surg Asia-Pacific 2024; 11 (1):25-28.
Schwannomas are benign, isolated, and encapsulated tumors originating from schwann cells of the peripheral nerve sheath. Schwannomas usually affect the head and neck region and localization in the lower extremity is exceptionally rare with a reported prevalence rate of 1–10%. A <20 cases of schwannomas of feet have been reported in the literature, most commonly causing compression in the tarsal tunnel, it is however rare for them to be seen more distally. We herein report a rare presentation of giant schwannoma of the foot diagnosed on either a magnetic resonance imaging (MRI) scan or ultrasound scan of the foot which revealed a well-defined, lobulated soft tissue lesion likely of fibrous or neural origin. Both patients underwent an excisional biopsy under spinal anesthesia, with an uneventful recovery period. The postoperative (post-op) follow-up was reported to be normal with no radiological evidence of recurrence. This report of two cases and the included literature review aims to highlight the diagnostic challenges of this rarely encountered entity and the authors hope to raise awareness of lower limb schwannomas and their clinical presentation.
Albert P, Patel J, Badawy K, et al. Peripheral nerve schwannoma: a review of varying clinical presentations and imaging findings. J Foot Ankle Surg 2017;56(3):632–637. DOI: 10.1053/j.jfas.2016.12.003
Carter J, Ben-Ghashir N, Chandrasekar CR. Giant schwannoma of the medialplantar nerve. Foot (Edinb) 2016;26:4–6. DOI: 10.1016/j.foot.2015.10.002
Flores Santos F, Pinheiro M, Felicissimo P. Large foot schwannoma with bone invasion - a case report. Foot Ankle Surg 2014;20(2):e23–e26. DOI: 10.1016/j.fas.2014.01.003
Tvrdek M. Malignant schwannoma of the planta. Acta Chir Plast 2001;43(3):77–79.
Zivot ML, Pitzer S, Pantig-Felix L, et al. Malignant schwannomaof the medial plantar branch of the posterior tibial nerve. J Foot Surg 1990;29(2):130–134.
GIANNESTRAS NJ, BRONSON JL. Malignant schwannoma of the medial plantar branch of the posterior tibial nerve (unassociated with von Recklinghausen's disease). A case report. J Bone Joint Surg Am 1975;57(5):701–703.
Ly P. Solitary benign schwannoma of the foot presenting clinically as a ganglion cyst (a case study). J Am Podiatry Med Assoc 2018;108(4):340–343. DOI: 10.7547/16-147
Torossian JM, Augey F, Salle M, et al. Giant foot schwannoma. Br J Plast Surg 2001;54(1):74–76. DOI: 10.1054/bjps.1999.3478
Mangrulkar VH, Brunetti VA, Gould ES, et al. Unusually large pedal schwannoma. J Foot Ankle Surg 2007;46(5):398–402. DOI: 10.1053/j.jfas.2007.06.002
Pasternack WA, Winter-Reiken DJ. Unusually large cellular schwannoma of the foot. J Am Podiatr Med Assoc 2005;95(2):157–160. DOI: 10.7547/0950157
Das Gupta TK, Brasfield RD, Strong EW, et al. Benign solitary schwannomas (neurilemomas). Cancer 1969;24(2):355–366. DOI: 10.1002/1097-0142(196908)24:2<355::aid-cncr2820240218>3.0.co;2-2
Kwok KB, Lui TH, Lo WN. Neurilemmoma of the first branch of the lateral plantarnerve causing tarsal tunnel syndrome. Foot Ankle Spec 2009;2(6):287–290. DOI: 10.1177/1938640009349868
Still GP. Neurilemoma of the medial plantar nerve: a case report. J Foot AnkleSurg 2001;40(4):236–239. DOI: 10.1016/s1067-2516(01)80024-7
Spiegl PV, Cullivan WT, Reiman HM, et al. Neurilemoma of thelower extremity. Foot Ankle 1986;6(4):194–198. DOI: 10.1177/107110078600600404
Ritt MJ, Bos KE. A very large neurilemmoma of the anterior interosseousnerve. J Hand Surg Br 1991;16(1):98–100. DOI: 10.1016/0266-7681(91)90141-a
Ansari MT, Rastogi S, Khan SA, Yadav C, Rijal L. Giant schwannoma of the first metatarsal: a rare entity. J Foot Ankle Surg 2014;53:335–359. DOI: 10.1053/j.jfas.2014.01.014.
Wang G, Wen X, Qu L, et al. Intraosseous schwannoma involving multiple bones of the foot: a case report. J Foot Ankle Surg 2016;55(1):201–206. DOI: 10.1053/j.jfas.2015.07.002.
Muratori F, De Gori M, Campo FR, et al. Giant schwannoma of the foot: a case report and literature review. Clin Cases Miner Bone Metab 2017;14(2):265–268. DOI: 10.11138/ccmbm/2017.14.2.265
Odom RD, Overbeek TD, Murdoch DP, et al. Neurilemoma of themedial plantar nerve: a case report and literature review. J Foot Ankle Surg 2001;40(2):105–109. DOI: 10.1016/s1067-2516(01)80052-1
Per-Lee JH, Clairmont AA. Acoustic neuroma in von Recklinghausen's disease. South Med J 1976;69(7):844–847. DOI: 10.1097/00007611-197607000-00009
Izumi AK, Rosato FE, Wood MG. Von Recklinghausen's disease associated with multiple neurolemomas. Arch Dermatol 1971;104(2):172–176.
Hao X, Levine D, Yim J, et al. Schwannoma of foot and ankle: seven case reports and literature review. Anticancer Res 2019,39(9):5185–5194. DOI: 10.21873/anticanres.13715
Angelini A, Bevoni R, Biz C, et al. Schwannoma of the foot: report of four cases and literature review. Acta Biomed 2019;90(1-S):214–220. DOI: 10.23750/abm.v90i1-S.8079
Majbar A, Hrora A, Jahid A, et al. Perineal schwannoma. BMC Res Notes 2016;9:304. DOI: 10.1186/s13104-016-2108-1