Journal of Foot and Ankle Surgery (Asia Pacific)

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VOLUME 10 , ISSUE 1 ( January-March, 2023 ) > List of Articles


Application of Amniotic Membrane Allograft in the Treatment of Foot and Ankle Pathologies: A Review of the Basic Science and Clinical Evidence

Hirotaka Nakagawa, Gregory R Waryasz, Alberto Panero, Walter I Sussman

Keywords : Amniotic graft, Amniotic membrane, Amniotic mesenchymal stem cells, Achilles tendonitis, Nerve wrap, Osteoarthritis, Plantar fasciitis

Citation Information : Nakagawa H, Waryasz GR, Panero A, Sussman WI. Application of Amniotic Membrane Allograft in the Treatment of Foot and Ankle Pathologies: A Review of the Basic Science and Clinical Evidence. J Foot Ankle Surg Asia-Pacific 2023; 10 (1):209-215.

DOI: 10.5005/jp-journals-10040-1274

License: CC BY-NC 4.0

Published Online: 31-12-2022

Copyright Statement:  Copyright © 2023; The Author(s).


Background: In recent years, an increasing number of studies have investigated the use of AM for various orthopedic indications. AM allografts’ anti-inflammatory and anti-scarring properties make them a promising agent used to augment the healing of pathological soft tissue. Purpose: The purpose of this study is to review the published studies on the use of amniotic membrane (AM)-derived allografts in human subjects for various indications in the foot and ankle. Results: Studies suggest that when it is used for the treatment of plantar fasciitis, the efficacy of AM-derived products is at least equivocal to corticosteroid injections in the short term and superior to placebo injection in the long term. Fewer studies have investigated the application of AM-derived products in Achilles tendinitis, ankle and foot osteoarthritis (OA), or peripheral nerve pathology. Conclusion: Additional high-quality supportive data is needed to support the efficacy and safety of AM-derived products in the foot and ankle. Furthermore, clinicians should be aware of the regulatory status of any AM-derived product before its use in clinical practice.

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